Accuracy of serum procalcitonin, C-reactive protein and soluble CD14 subtype levels in diagnosis of sepsis in children

Background/Aim. Despite the widespread use of procalcitonin, C-reactive protein (CRP), and soluble CD14 subtype (sCD14-ST), their diagnostic accuracy in children with sepsis is not yet clear. The aim study was to establish compare CRP, sCD14-ST admitted hospital under suspicion having sepsis. Methods. designed as a retrospective cross-sectional on Pediatrics Clinic Kragujevac, Serbia, sepsis, during 6-month period. Diagnostic tested by construction receiver operating characteristic (ROC) curves comparison terms area curve (AUC). Results. Procalcitonin had largest AUC [0.75; 95% confidence interval (CI) 0.63?0.88], followed CRP (0.68; CI 0.54?0.81) (0.65; 0.52 ? 0.79). Differences between areas ROC were significant (CRP vs. procalcitonin z = 1.054, p 0.291; 0.238, 0.812; 1.089, 0.286). Conclusion. Our showed relatively low sensitivity moderate specificity diagnosing among children, well similar three biomarkers.